Formed by a lipid bilayer membrane, designed to deliver drugs to tumors. They reach the tumor via the bloodstream and migrate through leaky tumor vessels.
However, only a small fraction of the liposomes reaches the tumor and only partially releases the drug, meaning it does not become fully bioavailable. At the same time, significant amounts of the liposomes are trapped in the liver and spleen. For these reasons, conventional liposomes have not achieved improved antitumor efficacy.
